Manufacturing of urea co-crystals by spiral gas–solid two-phase flow (S-GSF) based on spiral jet mills: a continuous, solvent-free, and scalable mechanochemical method

Literature Information

Publication Date 2023-11-01
DOI 10.1039/D3CE00833A
Impact Factor 3.545
Authors

Yong Song, Zhiyuan Jin, Jiawei Zhang, Bo Jin, Rufang Peng



Abstract

In this work, we report a spiral gas–solid two-phase flow (S-GSF) method based on spiral jet mills for the continuous mechanochemical preparation of urea co-crystals for the first time. Urea–adipic acid (UAA), urea–catechol (URCAT), urea–salicylic acid (USA) and urea–gypsum (URCASU) co-crystals were prepared to demonstrate the feasibility of this approach. The prepared products were characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. The results showed that powdered products of the urea co-crystals can be obtained continuously by using this method without the addition of any solvent in the preparation process. Moreover, the UAA co-crystal prepared by S-GSF is in single polycrystalline form I, while form II, which appears in milling and ball milling, is not observed. The transcrystallization behavior among different polymorphs of the UAA co-crystal was studied and their thermodynamic stability was investigated by theoretical calculations. The results indicated that form I is a thermodynamically stable polymorph, and S-GSF is selective for the formation of form I. This phenomenon can be attributed to the fact that S-GSF provides strong mechanical action, as well as a low-temperature reaction environment, which distinguishes it from existing mechanochemical methods.

Source Journal

CrystEngComm

CrystEngComm
CiteScore: 5.5
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CrystEngComm is the forum for the design and understanding of crystalline materials. We welcome studies on the investigation of molecular behaviour within crystals, control of nucleation and crystal growth, engineering of crystal structures, and construction of crystalline materials with tuneable properties and functions. We publish hypothesis-driven research into… how crystal design affects thermodynamics, phase transitional behaviours, polymorphism, morphology control, solid state reactivity (crystal-crystal solution-crystal, and gas-crystal reactions), optoelectronics, ferroelectric materials, non-linear optics, molecular and bulk magnetism, conductivity and quantum computing, catalysis, absorption and desorption, and mechanical properties. Using Techniques and methods including… Single crystal and powder X-ray, electron, and neutron diffraction, solid-state spectroscopy, spectrometry, and microscopy, modelling and data mining, and empirical, semi-empirical and ab-initio theoretical evaluations. On crystalline and solid-state materials. We particularly welcome work on MOFs, coordination polymers, nanocrystals, host-guest and multi-component molecular materials. We also accept work on peptides and liquid crystals. All papers should involve the use or development of a design or optimisation strategy. Routine structural reports or crystal morphology descriptions, even when combined with an analysis of properties or potential applications, are generally considered to be outside the scope of the journal and are unlikely to be accepted.

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