A novel drug–drug cocrystal of tegafur and myricetin: optimized properties of dissolution and tabletability
Literature Information
Min Zhang, Dai-Lin Gu, Jian-Feng Zhen, Tong-Bu Lu, Xia-Lin Dai, Jia-Mei Chen
Tegafur (TGF) is a broad-spectrum anti-tumor drug, but it suffers from fast metabolism and consequently poor oral absorption. Myricetin (MYR) is a flavonoid with anti-tumor activity and it has the potential to reverse the TGF resistance, but exhibits poor solubility and low oral bioavailability. In order to simultaneously optimize the physicochemical properties of TGF and MYR, and provide a solution for constructing a fixed-dose combination with better performance, a drug–drug cocrystal (TGF–MYR) was synthesized and comprehensively characterized. The cocrystal effectively improves the dissolution performance of MYR and delays the drug release of TGF, which is beneficial for reducing their solubility difference and improving the formulation compatibility. Moreover, the cocrystal demonstrates significantly improved tabletability compared to pure TGF and is less hygroscopic than pure MYR, as well as having good stability, which indicated there were good prospects for the development of TGF and MYR combined formulations in the future.
Related Literature
IF 6.367
Vapor-fed photoelectrolysis of water at 0.3 V using gas-diffusion photoanodes of SrTiO3 layersIF 6.367
Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammationIF 6.222
Transition metal chemistry in synthetically viable alkaline earth complexes M(Cp)3− (M = Ca, Sr, Ba)IF 6.222
Front coverIF 6.843
Contents listIF 6.843
Pulsed laser rusted stainless steel: a robust electrode material applied for energy storage and generation applicationsIF 6.367
Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunitiesIF 6.843
Near infrared light activation of an injectable whole-cell cancer vaccine for cancer immunoprophylaxis and immunotherapyIF 6.843
PEST (political, environmental, social & technical) analysis of the development of the waste-to-energy anaerobic digestion industry in China as a representative for developing countriesIF 6.367
Source Journal
CrystEngComm

CrystEngComm is the forum for the design and understanding of crystalline materials. We welcome studies on the investigation of molecular behaviour within crystals, control of nucleation and crystal growth, engineering of crystal structures, and construction of crystalline materials with tuneable properties and functions. We publish hypothesis-driven research into… how crystal design affects thermodynamics, phase transitional behaviours, polymorphism, morphology control, solid state reactivity (crystal-crystal solution-crystal, and gas-crystal reactions), optoelectronics, ferroelectric materials, non-linear optics, molecular and bulk magnetism, conductivity and quantum computing, catalysis, absorption and desorption, and mechanical properties. Using Techniques and methods including… Single crystal and powder X-ray, electron, and neutron diffraction, solid-state spectroscopy, spectrometry, and microscopy, modelling and data mining, and empirical, semi-empirical and ab-initio theoretical evaluations. On crystalline and solid-state materials. We particularly welcome work on MOFs, coordination polymers, nanocrystals, host-guest and multi-component molecular materials. We also accept work on peptides and liquid crystals. All papers should involve the use or development of a design or optimisation strategy. Routine structural reports or crystal morphology descriptions, even when combined with an analysis of properties or potential applications, are generally considered to be outside the scope of the journal and are unlikely to be accepted.