An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo
Literature Information
Ke-Bin Huang, Feng-Yang Wang, Hai-Wen Feng, Hejiang Luo, Yan Long, Albert S. C. Chan, Rong Liu, Huahong Zou, Zhen-Feng Chen, Yan-Cheng Liu, You-Nian Liu, Hong Liang
A platinum(II) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.
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