An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

Literature Information

Publication Date 2019-09-23
DOI 10.1039/C9CC06563F
Impact Factor 6.222
Authors

Ke-Bin Huang, Feng-Yang Wang, Hai-Wen Feng, Hejiang Luo, Yan Long, Albert S. C. Chan, Rong Liu, Huahong Zou, Zhen-Feng Chen, Yan-Cheng Liu, You-Nian Liu, Hong Liang



Abstract

A platinum(II) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

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