An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

文献信息

发布日期 2019-09-23
DOI 10.1039/C9CC06563F
影响因子 6.222
作者

Ke-Bin Huang, Feng-Yang Wang, Hai-Wen Feng, Hejiang Luo, Yan Long, Albert S. C. Chan, Rong Liu, Huahong Zou, Zhen-Feng Chen, Yan-Cheng Liu, You-Nian Liu, Hong Liang



摘要

A platinum(II) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.

来源期刊

Chemical Communications

Chemical Communications
CiteScore: 8.6
自引率: 4.7%
年发文量: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

推荐供应商

中国台州市椒江天一化工厂
中国乔克电子排水阀上海销售公司
中国浙江华晟化学制品有限公司
中国Changzhou Suntton Co., Ltd.
中国力码(广州)材料科技有限公司
中国江苏万淇生物科技股份有限公司
德国Scheidt-Ventilatoren GmbH
中国瑞纳森(常州)国际贸易有限公司
中国西安博康兴业食用化工有限公司
中国盐城远东化工有限公司
免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 [email protected] 联系我们。我们将及时核实并处理您的问题。