Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging
Literature Information
Lalit N. Goswami, Aslam A. Khan, Satish S. Jalisatgi, M. Frederick Hawthorne
The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (19F) magnetic resonance spectroscopy (19F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B122−-core via suitable linkers. The 19F-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.
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Chemical Communications
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