Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo
文献信息
Liming Wang, Mengmeng Pan, Rui Cai, Hao Yuan, Wanxia Huang, Qingxi Yuan, Yunlong Zhou
It is unknown how the identity provided by protein coronas on the surface of chiral nanoparticles determines their blood circulation, distribution, and clearance fates of the nanoparticles in vivo. Here, we attempt to investigate how the mirrored surface of gold nanoparticles with distinct chirality reshapes the coronal composition that mediates their subsequent clearance from blood and biodistribution. We found that chiral gold nanoparticles exhibited surface chirality-specific recognition for the coronal components, including the lipoproteins, complement components, and acute phase proteins, ultimately resulting in distinct cell uptake and tissue accumulation in vivo. We observed that these stereoselective behaviors were correlated to subgroups of the corona composition that could bind to low-density lipoprotein receptors. Therefore, this study reveals how chirality-specific protein compositions selectively recognize and interact with cell receptors for chirality-mediated tissue accumulation. This study will deepen our understanding of how chiral nanoparticles/nanomedicine/nanocarriers interact with biological systems to guide the efficient fabrication of target nanomedicines.
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来源期刊
Nanoscale Horizons
Nanoscale Horizons is a leading journal for the publication of exceptionally high-quality, innovative nanoscience and nanotechnology. The journal places an emphasis on original research that demonstrates a new concept or a new way of thinking (a conceptual advance), rather than primarily reporting technological improvements. However, outstanding articles featuring truly breakthrough developments such as record performance alone may also be published in the journal. For work to be published it must be of significant general interest to our community-spanning readership. Topics covered in the journal include, but are not limited to: Synthesis of nanostructured and nanoscale materials Quantum materials 2D materials Layered materials Layered quantum materials Characterisation of functional nanoscale materials and bio-assemblies Properties of nanoscale materials Self-assembly and molecular organisation Complex hybrid nanostructures Nanocomposites, nanoparticles, nanocrystalline materials, and nanoclusters Nanotubes, molecular nanowires and nanocrystals Molecular nanoscience Nanocatalysis Theoretical modelling Single-molecules Plasmonics Nanoelectronics and molecular electronics Nanophotonics Nanochips, nanosensors, nanofluidics and nanofabrication Carbon-based nanoscale materials and devices Biomimetic materials Nanobiotechnology/bionanomaterials Nanomedicine Regulatory approaches and risk assessment
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