Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo

文献情報

出版日 2023-05-22
DOI 10.1039/D3NH00124E
インパクトファクター 10.989
著者

Liming Wang, Mengmeng Pan, Rui Cai, Hao Yuan, Wanxia Huang, Qingxi Yuan, Yunlong Zhou



要旨

It is unknown how the identity provided by protein coronas on the surface of chiral nanoparticles determines their blood circulation, distribution, and clearance fates of the nanoparticles in vivo. Here, we attempt to investigate how the mirrored surface of gold nanoparticles with distinct chirality reshapes the coronal composition that mediates their subsequent clearance from blood and biodistribution. We found that chiral gold nanoparticles exhibited surface chirality-specific recognition for the coronal components, including the lipoproteins, complement components, and acute phase proteins, ultimately resulting in distinct cell uptake and tissue accumulation in vivo. We observed that these stereoselective behaviors were correlated to subgroups of the corona composition that could bind to low-density lipoprotein receptors. Therefore, this study reveals how chirality-specific protein compositions selectively recognize and interact with cell receptors for chirality-mediated tissue accumulation. This study will deepen our understanding of how chiral nanoparticles/nanomedicine/nanocarriers interact with biological systems to guide the efficient fabrication of target nanomedicines.

掲載誌

Nanoscale Horizons

Nanoscale Horizons
CiteScore: 16.3
自己引用率: 3.4%
年間論文数: 138

Nanoscale Horizons is a leading journal for the publication of exceptionally high-quality, innovative nanoscience and nanotechnology. The journal places an emphasis on original research that demonstrates a new concept or a new way of thinking (a conceptual advance), rather than primarily reporting technological improvements. However, outstanding articles featuring truly breakthrough developments such as record performance alone may also be published in the journal. For work to be published it must be of significant general interest to our community-spanning readership. Topics covered in the journal include, but are not limited to: Synthesis of nanostructured and nanoscale materials Quantum materials 2D materials Layered materials Layered quantum materials Characterisation of functional nanoscale materials and bio-assemblies Properties of nanoscale materials Self-assembly and molecular organisation Complex hybrid nanostructures Nanocomposites, nanoparticles, nanocrystalline materials, and nanoclusters Nanotubes, molecular nanowires and nanocrystals Molecular nanoscience Nanocatalysis Theoretical modelling Single-molecules Plasmonics Nanoelectronics and molecular electronics Nanophotonics Nanochips, nanosensors, nanofluidics and nanofabrication Carbon-based nanoscale materials and devices Biomimetic materials Nanobiotechnology/bionanomaterials Nanomedicine Regulatory approaches and risk assessment

おすすめサプライヤー

スイスブッカー・インダストリーズ
中国安徽南方化学ポンプ有限公司
中国ジンエン(広州)新材料有限公司
中国镇江市海通化工有限公司
スイスEmile Egger&Cie SA
中国桐乡市化工有限公司
ドイツマシン · メッシャー
ドイツPiller Industrieventilatoren GmbH
中国山西德之北金属材料有限公司
中国陕西省晨曦之光化学科技有限公司
免責事項
このページに表示される学術雑誌情報は、参考および研究目的のみを目的としています。当社は雑誌出版社とは提携しておらず、投稿の取り扱いも行っておりません。出版に関するお問い合わせは、各雑誌出版社に直接ご連絡ください。
表示されている情報に誤りがある場合は、[email protected] までご連絡ください。迅速に確認し、対応いたします。