Impact of residence time distributions in reacting magnesium packed beds on Grignard reagent formation – selectivity of Grignard reagent formation (part 2)
Literature Information
Michael Maskos, Gabriele Menges-Flanagan, Dirk Ziegenbalg
Grignard reagents are used as intermediates in the production of complex molecules, since they can be used to form new carbon–carbon bonds, e.g. in the formation of active pharmaceutical ingredients. Side product formation like Wurtz coupling diminishes the selectivity in Grignard reagent formation and therefore side product formation needs to be reduced. It was found that the different pumping behaviours of a syringe pump, a valveless rotary piston pump and a micro annular gear pump and the obtained residence time distributions have an impact on the selectivity of the Grignard reagent formation. Selectivity can also be enhanced by the available magnesium surface and by choosing a tubular flow reactor instead of a batch reactor, showing the importance of choosing the right equipment and parameters for the specific reaction system.
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Reaction Chemistry & Engineering
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
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