Stabilizing synthetic DNA for long-term data storage with earth alkaline salts
Literature Information
A. Xavier Kohll, Philipp L. Antkowiak, Weida D. Chen, Bichlien H. Nguyen, Wendelin J. Stark, Luis Ceze, Karin Strauss, Robert N. Grass
Rapid aging tests (70 °C, 50% RH) of solid state DNA dried in the presence of various salt formulations, showed the strong stabilizing effect of calcium phosphate, calcium chloride and magnesium chloride, even at high DNA loadings (>20 wt%). A DNA-based digital information storage system utilizing the stabilizing effect of MgCl2 was tested by storing a DNA file, encoding 115 kB of digital data, and the successful readout of the file by sequencing after accelerated aging.
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Chemical Communications

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