Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid
Literature Information
Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima
A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.
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Chemical Communications

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