Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Literature Information

Publication Date 2007-08-10
DOI 10.1039/B708947C
Impact Factor 6.222
Authors

Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima



Abstract

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

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