A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture

文献情報

出版日 2023-10-12
DOI 10.1039/D3BM00753G
インパクトファクター 6.843
著者

Katie J. Sikes, David D. Frisbie, Nikki Phillips, Brad B. Nelson, C. Wayne McIlwraith, Chris E. Kawcak, Laurie R. Goodrich



要旨

We report the relationships between linear vs. network polymer architecture and biomechanical outcomes including lubrication and cushioning when the polymers are applied to the surface of articulating knee cartilage. Aqueous formulations of the bioinspired polymer poly(2-methacryloyloxylethyl phosphorylcholine) (pMPC) exhibit tuneable rheological properties, with network pMPC exhibiting increased elasticity and viscosity compared to linear pMPC. Application of a polymer network, compared to a linear one, to articulating tissue surfaces reduces friction, lessens tissue strain, minimizes wear, and protects tissue – thereby improving overall tissue performance. Administration of the network pMPC to the middle carpal joint of skeletally mature horses elicits a safe response similar to saline as monitored over a 70 day period.

掲載誌

Biomaterials Science

Biomaterials Science
CiteScore: 11.5
自己引用率: 3.4%
年間論文数: 492

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods

おすすめサプライヤー

フランスVerrerie Soufflée Mécanique (VSM) S.A.
ドイツABB AG
ドイツVulkan-Verlag GmbH
オーストリアWaagen Scheffknecht有限公司
中国佛山市ノ銀貴金属材料有限公司
イギリスBaerlocher英国
中国南京定达メディカルテクノロジーコーポレーション
ドイツスタインハウス
中国ドイツ・ライコー・リミテッド北京代表处
中国武汉博欧特生物科技有限公司
免責事項
このページに表示される学術雑誌情報は、参考および研究目的のみを目的としています。当社は雑誌出版社とは提携しておらず、投稿の取り扱いも行っておりません。出版に関するお問い合わせは、各雑誌出版社に直接ご連絡ください。
表示されている情報に誤りがある場合は、[email protected] までご連絡ください。迅速に確認し、対応いたします。