Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effective protein refolding

文献情報

出版日 2013-10-28
DOI 10.1039/C3RA44572K
インパクトファクター 3.361
著者

Shigeo Takeda, Haruko Takahashi, Yoshihiro Sasaki



要旨

Enzymatically synthesized glycogen (ESG) bearing hydrophobic groups were prepared to construct a new artificial molecular chaperone system. The radius of the amphiphilic ESG nanogel was approximately 15 nm. The nanogels prevented irreversible aggregation of carbonic anhydrase. Cyclodextrin induced the release of carbonic anhydrase in its active form via a one-step mechanism without dissociation of the nanogels.

掲載誌

RSC Advances

RSC Advances
CiteScore: 7.5
自己引用率: 2.6%
年間論文数: 3122

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