Dithiocarbazate–Zn(ii) complexes for photodynamic therapy and chemotherapy against lung cancer
文献信息
JunGang Deng, YouRu Wu, AiLi Li, WeiPing Pan, LiXia Hou, DaQi Wu, ZhenLei Zhang, Feng Yang
Combining photodynamic therapy with chemotherapy is a promising strategy for treating tumors. Herein, a series of new dithiocarbazate–Zn(II) complexes, including [ZnII(L1)2] Zn1, [ZnII(L2)2] Zn2, [ZnII(L3)2] Zn3, and [ZnII(L4)2] Zn4, have been synthesized for chemotherapy and photodynamic therapy of lung cancer. These complexes can be used for live-cell fluorescence-based imaging, are photostable, and exhibit hemolysis comparable to cisplatin. Among them, complex Zn3 shows good chemotherapeutic ability, and its chemotherapeutic mechanism relies on multiple pathways. At the same time, complex Zn3 generates superoxide anion radicals (˙O2−) under light irradiation, leading to cancer cell death through photodynamic therapy. Its remarkable anticancer effect is achieved through multimodal photodynamic therapy/chemotherapy. This study paves the way for the use of novel Zn(II) complexes as anticancer agents, providing new strategies for multimodal cancer therapy.
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来源期刊
Inorganic Chemistry Frontiers
Inorganic Chemistry Frontiers publishes research articles, reviews, notes, comments and methods covering all areas of inorganic chemistry. Emphases are placed on interdisciplinary studies where inorganic chemistry and organometallic chemistry meet related areas, such as catalysis, biochemistry, nanoscience, energy and materials science. For publication in Inorganic Chemistry Frontiers, papers should report high-quality work of exceptional novelty, which will be of significant interest to the wide readership of the journal.
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