Carbon network-hosted porphyrin as a highly biocompatible nanophotosensitizer for enhanced photodynamic therapy
文献信息
Min Wang, Yanlin Zheng, Huaming He, Tong Lv, Xin Xu, Xiao Fang, Chunhua Lu, Huanghao Yang
Photodynamic therapy (PDT) has the characteristics of being simple and non-invasive, and with on-demand light control. However, most photosensitizers exhibit strong hydrophobicity, low quantum yields in water and low tumor selectivity. In this study, carbon network-hosted porphyrins (CPs) with high biocompatibility and efficient singlet oxygen (1O2) generation were developed to reduce the biotoxicity of photosensitizers and avoid quenching caused by hydrophobic aggregation for enhanced PDT. The CPs were prepared by a simple solid-phase synthesis method using porphyrin, green non-toxic citric acid and urea as the raw materials. The CPs exhibited excellent water solubility and high biocompatibility. Even when the concentration reached 1.5 mg mL−1, cells still had good biological activity. By separately fixing the porphyrins in the carbon network, the CPs avoided aggregation-induced inactivation and had high generation efficiency of 1O2. Furthermore, in order to improve the PDT effect, the CPs were modified with the upper nuclear targeting peptide TAT (T-CPs), which was used to target the nucleus and generate 1O2in situ to directly destroy genetic material. The proposed strategy provides a simple and green path to prepare nanophotosensitizers with high biocompatibility and efficient 1O2 generation for PDT.
相关文献
IF 6.843
A new neodymium–phosphine compound for supercapacitors with long-term cycling stabilityIF 6.222
Carbon-based photocatalysts for enhanced photocatalytic reduction of CO2 to solar fuelsIF 6.367
Life cycle assessment of plasma-assisted ethylene production from rich-in-methane gas streamsIF 6.367
The dilemma between acid and base catalysis in the synthesis of benzimidazole from o-phenylenediamine and carbon dioxide‡IF 6.222
Tessellation strategy for the interfacial synthesis of an anthracene-based 2D polymer via [4+4]-photocycloadditionIF 6.222
Engineering nanoporous organic frameworks to stabilize naked Au clusters: a charge modulation approachIF 6.222
CaMoO4 nanosheet arrays for efficient and durable water oxidation electrocatalysis under alkaline conditionsIF 6.222
Performance of electrode-supported silica membrane separators in lithium-ion batteriesIF 6.367
An environmentally friendly natural polymer as a universal interfacial modifier for fullerene and non-fullerene polymer solar cellsIF 6.367
来源期刊
Biomaterials Science
Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods
![503070-57-3 - 2-[2-(6-溴己氧基)乙氧基甲基]-1,3-二氯苯](/structs/503/503070-57-3-bc25.webp "503070-57-3 - 2-[2-(6-溴己氧基)乙氧基甲基]-1,3-二氯苯")
推荐供应商
Systec GmbH&Co.KG库卡系统有限公司Berghof有限公司
襄樊诺尔化工有限公司星鑫科贸有限公司宝鸡宝冶钛镍制造有限责任公司戴科化学贸易化学(上海)有限公司
调查社蚌埠一苇化学材料销售有限公司PMR TechUG(轴承式机械设备)