Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes
文献信息
Dan Shao, Jing Li, Yue Pan, Xin Zhang, Xiao Zheng, Zheng Wang, Ming Zhang, Hong Zhang
Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nanotechnology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of an HSV-TK suicide gene covalently coupling with near-infrared fluorescent CdSeTe/ZnS core/shell quantum dots. The liver cancer-targeting and biosafety of FL/QD-TK were studied in vitro and in vivo. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the folate receptor-overexpressed Bel-7402 mouse xenografts without systematic toxicity. This study may shed light on gene delivery and targeted cancer therapy.
相关文献
IF 4.616
Monitoring of cellular behaviors by microcavity array-based single-cell patterningIF 4.616
Comparison of aggregating agents for the surface-enhanced Raman analysis of benzodiazepinesIF 4.616
Realizing nano electrospray ionization using disposable pipette tips under super atmospheric pressureIF 4.616
Kaajal fights against eye pathogens and is safe for eye make-up: a reinvestigation of an ancient practiceIF 4.616
A novel and photostable pH probe for selectively staining nuclei in living cellsIF 4.616
Design of a universal biointerface for sensitive, selective, and multiplex detection of biomarkers using surface plasmon resonance imagingIF 4.616
A GFP-tagged nucleoprotein-based aggregation assay for anti-influenza drug discovery and antibody developmentIF 4.616
Colorimetric and fluorescent dual detection of paraquat and diquat based on an anionic polythiophene derivativeIF 4.616
Melamine modified gold nanoprobe for “on-spot” colorimetric recognition of clonazepam from biological specimensIF 4.616
来源期刊
Biomaterials Science

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods