Recent advances in trifluoroethylation reaction
Literature Information
Publication Date
2023-10-04
DOI
10.1039/D3QO01366A
Impact Factor
5.281
Authors
Ming-Xi Zhou, Shuai Han, Yue Wang, Wei Zhang, Yao-Fu Zeng
View Original
Abstract
Trifluoroethyl group serving as the bioisostere of ethyl or ethoxy group widely exists in the fields of pharmaceuticals and agrochemicals. Developing novel strategies for introducing trifluoroethyl group into various skeletons has become a hot topic in organic synthetic chemistry. In this review, the trifluoroethylation reactions on various compounds such as alkynes, alkenes, functionalized arenes, amines, and so on were summarized. This review is categorized into four parts based on the bond formation: C(sp)–CH2CF3, C(sp2)–CH2CF3, C(sp3)–CH2CF3, and X (X = N, O, S, and Se)–CH2CF3. Some representative examples along with reaction mechanisms were also discussed.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure](https://static.chemtradehub.com/structs/500/500789-04-8-20dd.webp "(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure")
(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid
CAS Number:
500789-04-8
Molecular Formula:
C14H18FNO4
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