Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

文献情報

出版日 2023-09-26
DOI 10.1039/D3CE00807J
インパクトファクター 3.545
著者

Peiyi Liang, Yi Hu, Zhuxian Wang, Yinglin Guo, Hongkai Chen, CuiPing Jiang, Quanfu Zeng, Chunyan Shen, Yufan Wu, Li Liu, Yankui Yi, Hongxia Zhu, Zhijun Yang, Qiang Liu



要旨

Glabridin (Gla) is a natural active ingredient extracted from licorice root with good whitening activity. However, its poor solubility limits its further application. Therefore, this study aimed to develop a novel co-amorphous Gla–OMT raw material using oxymatrine (OMT) as a co-former, aiming to improve its physicochemical properties and enhance its whitening activity. Firstly, the formation of co-amorphous Gla–OMT was confirmed by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC). Subsequently, FT-IR, NMR, and molecular dynamics simulations were used to investigate the interaction between the co-amorphous Gla–OMT molecules, and solubility experiments and supersaturation dissolution experiments were used to investigate the solubilization of the co-amorphous Gla–OMT. In addition, the in vitro release mechanism of the co-amorphous Gla–OMT was investigated using a Franz diffusion cell and its biosafety and whitening activity were evaluated using cell experiments. In conclusion, the successful preparation of co-amorphous Gla–OMT and the evaluation of its whitening activity in this study have significant implications for guiding the development and application of whitening products in the future.

掲載誌

CrystEngComm

CrystEngComm
CiteScore: 5.5
自己引用率: 7.7%
年間論文数: 643

CrystEngComm is the forum for the design and understanding of crystalline materials. We welcome studies on the investigation of molecular behaviour within crystals, control of nucleation and crystal growth, engineering of crystal structures, and construction of crystalline materials with tuneable properties and functions. We publish hypothesis-driven research into… how crystal design affects thermodynamics, phase transitional behaviours, polymorphism, morphology control, solid state reactivity (crystal-crystal solution-crystal, and gas-crystal reactions), optoelectronics, ferroelectric materials, non-linear optics, molecular and bulk magnetism, conductivity and quantum computing, catalysis, absorption and desorption, and mechanical properties. Using Techniques and methods including… Single crystal and powder X-ray, electron, and neutron diffraction, solid-state spectroscopy, spectrometry, and microscopy, modelling and data mining, and empirical, semi-empirical and ab-initio theoretical evaluations. On crystalline and solid-state materials. We particularly welcome work on MOFs, coordination polymers, nanocrystals, host-guest and multi-component molecular materials. We also accept work on peptides and liquid crystals. All papers should involve the use or development of a design or optimisation strategy. Routine structural reports or crystal morphology descriptions, even when combined with an analysis of properties or potential applications, are generally considered to be outside the scope of the journal and are unlikely to be accepted.

おすすめサプライヤー

中国⬇チーム進化化学工業有限公司
中国武汉弘徳悦欣薬科技有限公司
中国西安サンスタッド洗浄設備有限公司
ドイツハートン · アラゲンテクニク GmbH
中国上海芯上工業テクノロジーカンパニー LTD
ドイツブクラー GmbH
ドイツタイツカ工業ガス GmbH
中国深圳市優品生物科技有限公司発売 Branch Office
中国Enlight City Kengei Seiri Co., Ltd.
ドイツBertrandt Services GmbH
免責事項
このページに表示される学術雑誌情報は、参考および研究目的のみを目的としています。当社は雑誌出版社とは提携しておらず、投稿の取り扱いも行っておりません。出版に関するお問い合わせは、各雑誌出版社に直接ご連絡ください。
表示されている情報に誤りがある場合は、[email protected] までご連絡ください。迅速に確認し、対応いたします。