Construction of quaternary carbon centers by KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes
文献情報
Shang Wang, Yunfei Xiang, Tiantian Chen, Xiang Wu, Dong Xing
We report a KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes. With this transition metal-free and atom-economical protocol, a variety of α-homoallylic alkylated lactams bearing α-quaternary carbon centers were formed in a 2,1-addition manner with excellent regioselectivity. A cation–π interaction between the in situ-generated potassium enolate and the diene is proposed to play a key role in accelerating this transformation.
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Organic Chemistry Frontiers
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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